Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
bkrb1_human | 59 | 1.54x54 | TM1 | L => CysfsTer11 | frameshift | 8.237e-06 | 1 | 121400 | 0 | None | None | |
bkrb1_human | 70 | 2.37x37 | TM2 | N => LysfsTer14 | frameshift | 8.238e-06 | 1 | 121392 | 0 | None | None | |
bkrb1_human | 87 | 2.54x54 | TM2 | V => CysfsTer16 | frameshift | 8.238e-06 | 1 | 121392 | 0 | None | None | |
bkrb1_human | 102 | 23.49x49 | ECL1 | N => Ter | frameshift | 8.239e-06 | 1 | 121372 | 0 | None | None | |
bkrb1_human | 158 | 4.46x46 | TM4 | C => Ter | stop gained | 8.73e-06 | 1 | 114552 | 0 | None | None | |
bkrb1_human | 166 | 4.54x54 | TM4 | G => AlafsTer3 | frameshift | 8.652e-06 | 1 | 115576 | 0 | None | None | |
bkrb1_human | 172 | 4.60x61 | TM4 | T => HisfsTer25 | frameshift | 8.501e-06 | 1 | 117640 | 0 | None | None | |
bkrb1_human | 179 | ECL2 | Q => Ter | stop gained | 1.657e-05 | 2 | 120676 | 0 | None | None | ||
bkrb1_human | 230 | 5.66x66 | TM5 | R => Ter | stop gained | 2.472e-05 | 3 | 121348 | 0 | None | None | GP (contact) |
bkrb1_human | 282 | ECL3 | R => Ter | stop gained | 0.002833 | 344 | 121408 | 2 | None | None | ||
bkrb1_human | 278 | 6.63x63 | TM6 | V => Ter | stop gained | 8.116e-05 | 1 | 12322 | 0 | None | None | |
bkrb1_human | 4 | N-term | S => F | missense | 8.734e-06 | 1 | 114490 | 0 | 0.0 | 0.571 | ||
bkrb1_human | 7 | N-term | P => L | missense | 8.54e-06 | 1 | 117096 | 0 | nan | 0.007 | ||
bkrb1_human | 9 | N-term | E => A | missense | 8.453e-06 | 1 | 118296 | 0 | 0.21 | 0.011 | ||
bkrb1_human | 10 | N-term | L => F | missense | 4.219e-05 | 5 | 118520 | 0 | 0.33 | 0.014 | ||
bkrb1_human | 15 | N-term | Q => K | missense | 8.328e-06 | 1 | 120076 | 0 | 0.05 | 0.161 | ||
bkrb1_human | 16 | N-term | S => R | missense | 8.315e-06 | 1 | 120264 | 0 | 0.03 | 0.979 | ||
bkrb1_human | 16 | N-term | S => G | missense | 8.315e-06 | 1 | 120264 | 0 | 0.0 | 0.907 | ||
bkrb1_human | 18 | N-term | L => P | missense | 3.316e-05 | 4 | 120610 | 0 | 0.3 | 0.006 | ||
bkrb1_human | 19 | N-term | F => L | missense | 0.0001077 | 13 | 120672 | 0 | 0.35 | 0.002 | ||
bkrb1_human | 21 | N-term | Q => R | missense | 1.655e-05 | 2 | 120824 | 0 | 0.28 | 0.19 | ||
bkrb1_human | 24 | N-term | T => M | missense | 0.0001157 | 14 | 120972 | 0 | 0.0 | 0.995 | ||
bkrb1_human | 29 | N-term | A => P | missense | 3.301e-05 | 4 | 121168 | 0 | 0.17 | 0.864 | ||
bkrb1_human | 30 | 1.25x25 | TM1 | P => S | missense | 8.252e-06 | 1 | 121190 | 0 | 0.3 | 0.017 | |
bkrb1_human | 30 | 1.25x25 | TM1 | P => L | missense | 8.251e-06 | 1 | 121192 | 0 | 0.11 | 0.005 | |
bkrb1_human | 32 | 1.27x27 | TM1 | A => G | missense | 8.249e-06 | 1 | 121230 | 0 | 0.07 | 0.493 | |
bkrb1_human | 34 | 1.29x29 | TM1 | D => V | missense | 0.0001732 | 21 | 121268 | 0 | 0.02 | 0.735 | |
bkrb1_human | 34 | 1.29x29 | TM1 | D => G | missense | 8.246e-06 | 1 | 121268 | 0 | 0.08 | 0.034 | |
bkrb1_human | 41 | 1.36x36 | TM1 | P => L | missense | 0.0008899 | 108 | 121356 | 0 | 0.0 | 1.0 | |
bkrb1_human | 46 | 1.41x41 | TM1 | S => F | missense | 8.237e-06 | 1 | 121398 | 0 | 0.11 | 0.263 | |
bkrb1_human | 51 | 1.46x46 | TM1 | G => S | missense | 5.769e-05 | 7 | 121348 | 0 | 0.01 | 0.922 | |
bkrb1_human | 55 | 1.50x50 | TM1 | N => H | missense | 8.237e-06 | 1 | 121402 | 0 | 0.0 | 1.0 | |
bkrb1_human | 55 | 1.50x50 | TM1 | N => K | missense | 8.237e-06 | 1 | 121400 | 0 | 0.0 | 1.0 | |
bkrb1_human | 56 | 1.51x51 | TM1 | L => F | missense | 5.766e-05 | 7 | 121400 | 0 | 0.07 | 0.2 | |
bkrb1_human | 56 | 1.51x51 | TM1 | L => P | missense | 8.237e-06 | 1 | 121398 | 0 | 0.01 | 0.95 | |
bkrb1_human | 60 | 1.55x55 | TM1 | L => S | missense | 3.295e-05 | 4 | 121400 | 0 | 0.43 | 0.002 | |
bkrb1_human | 66 | 12.48x48 | ICL1 | R => W | missense | 1.648e-05 | 2 | 121386 | 0 | 0.02 | 0.212 | |
bkrb1_human | 66 | 12.48x48 | ICL1 | R => Q | missense | 8.239e-06 | 1 | 121380 | 0 | 0.05 | 0.463 | |
bkrb1_human | 67 | 12.49x49 | ICL1 | R => W | missense | 0.0001401 | 17 | 121368 | 0 | 0.05 | 0.091 | |
bkrb1_human | 67 | 12.49x49 | ICL1 | R => Q | missense | 8.238e-06 | 1 | 121392 | 0 | 0.48 | 0.043 | |
bkrb1_human | 70 | 2.37x37 | TM2 | N => K | missense | 8.238e-06 | 1 | 121388 | 0 | 0.41 | 0.019 | |
bkrb1_human | 71 | 2.38x38 | TM2 | V => L | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.501 | |
bkrb1_human | 71 | 2.38x38 | TM2 | V => M | missense | 8.238e-06 | 1 | 121394 | 0 | 0.0 | 0.931 | |
bkrb1_human | 71 | 2.38x38 | TM2 | V => A | missense | 3.295e-05 | 4 | 121390 | 0 | 0.07 | 0.058 | |
bkrb1_human | 74 | 2.41x41 | TM2 | I => N | missense | 1.648e-05 | 2 | 121390 | 0 | 0.0 | 0.954 | |
bkrb1_human | 76 | 2.43x43 | TM2 | L => M | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 1.0 | |
bkrb1_human | 83 | 2.50x50 | TM2 | D => A | missense | 4.119e-05 | 5 | 121392 | 0 | 0.0 | 1.0 | |
bkrb1_human | 90 | 2.57x57 | TM2 | L => F | missense | 8.238e-06 | 1 | 121384 | 0 | 0.01 | 1.0 | |
bkrb1_human | 94 | 2.61x61 | TM2 | A => E | missense | 4.943e-05 | 6 | 121386 | 0 | 0.0 | 1.0 | |
bkrb1_human | 96 | 2.63x63 | TM2 | N => S | missense | 8.238e-06 | 1 | 121388 | 0 | 0.01 | 0.943 | |
bkrb1_human | 97 | 2.64x64 | TM2 | I => L | missense | 8.238e-06 | 1 | 121386 | 0 | 0.01 | 0.548 | |
bkrb1_human | 106 | 3.21x21 | TM3 | G => R | missense | 2.474e-05 | 3 | 121258 | 0 | 0.0 | 0.999 | |
bkrb1_human | 111 | 3.26x26 | TM3 | R => C | missense | 3.306e-05 | 4 | 120980 | 0 | 0.01 | 0.984 | |
bkrb1_human | 111 | 3.26x26 | TM3 | R => G | missense | 8.266e-06 | 1 | 120980 | 0 | 0.0 | 0.89 | |
bkrb1_human | 111 | 3.26x26 | TM3 | R => H | missense | 1.654e-05 | 2 | 120952 | 0 | 0.0 | 0.977 | |
bkrb1_human | 114 | 3.29x29 | TM3 | N => K | missense | 0.0001495 | 18 | 120430 | 0 | 0.0 | 0.968 | LB (Van der Waals) |
bkrb1_human | 115 | 3.30x30 | TM3 | G => R | missense | 8.308e-06 | 1 | 120360 | 0 | 0.01 | 0.998 | |
bkrb1_human | 115 | 3.30x30 | TM3 | G => W | missense | 8.308e-06 | 1 | 120360 | 0 | 0.0 | 1.0 | |
bkrb1_human | 116 | 3.31x31 | TM3 | V => F | missense | 8.321e-06 | 1 | 120176 | 0 | 0.1 | 0.854 | |
bkrb1_human | 117 | 3.32x32 | TM3 | I => V | missense | 8.338e-06 | 1 | 119926 | 0 | 0.03 | 0.779 | LB (hydrophobic, Van der Waals) |
bkrb1_human | 120 | 3.35x35 | TM3 | N => S | missense | 5.023e-05 | 6 | 119460 | 0 | 0.0 | 0.949 | |
bkrb1_human | 121 | 3.36x36 | TM3 | L => F | missense | 1.679e-05 | 2 | 119154 | 0 | 0.01 | 0.997 | LB (hydrophobic, Van der Waals) |
bkrb1_human | 123 | 3.38x38 | TM3 | I => V | missense | 8.413e-06 | 1 | 118860 | 0 | 0.18 | 0.034 | |
bkrb1_human | 133 | 3.48x48 | TM3 | Q => R | missense | 8.572e-06 | 1 | 116662 | 0 | 0.32 | 0.015 | |
bkrb1_human | 135 | 3.50x50 | TM3 | R => C | missense | 8.621e-05 | 10 | 116002 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
bkrb1_human | 135 | 3.50x50 | TM3 | R => L | missense | 3.46e-05 | 4 | 115610 | 0 | 0.0 | 0.998 | SodiumPocket MicroSwitch GP (contact) |
bkrb1_human | 135 | 3.50x50 | TM3 | R => H | missense | 2.595e-05 | 3 | 115610 | 0 | 0.0 | 0.999 | SodiumPocket MicroSwitch GP (contact) |
bkrb1_human | 137 | 3.52x52 | TM3 | R => C | missense | 3.464e-05 | 4 | 115464 | 0 | 0.13 | 0.011 | |
bkrb1_human | 138 | 3.53x53 | TM3 | V => M | missense | 1.736e-05 | 2 | 115238 | 0 | 0.0 | 0.763 | GP (contact) |
bkrb1_human | 138 | 3.53x53 | TM3 | V => L | missense | 8.678e-06 | 1 | 115238 | 0 | 0.04 | 0.028 | GP (contact) |
bkrb1_human | 141 | 3.56x56 | TM3 | H => Y | missense | 7.844e-05 | 9 | 114744 | 0 | 0.08 | 0.045 | GP (contact) |
bkrb1_human | 141 | 3.56x56 | TM3 | H => R | missense | 8.713e-06 | 1 | 114766 | 0 | 0.13 | 0.687 | GP (contact) |
bkrb1_human | 143 | 34.51x51 | ICL2 | M => V | missense | 2.62e-05 | 3 | 114514 | 0 | 0.07 | 0.018 | GP (contact) |
bkrb1_human | 143 | 34.51x51 | ICL2 | M => R | missense | 3.495e-05 | 4 | 114444 | 0 | 0.04 | 0.064 | GP (contact) |
bkrb1_human | 146 | 34.54x54 | ICL2 | R => W | missense | 7.012e-05 | 8 | 114094 | 0 | 0.08 | 0.041 | GP (contact) |
bkrb1_human | 146 | 34.54x54 | ICL2 | R => Q | missense | 2.63e-05 | 3 | 114090 | 0 | 0.27 | 0.104 | GP (contact) |
bkrb1_human | 147 | 34.55x55 | ICL2 | R => G | missense | 8.766e-06 | 1 | 114074 | 0 | 0.27 | 0.015 | GP (contact) |
bkrb1_human | 149 | 4.37x37 | TM4 | Q => R | missense | 8.78e-06 | 1 | 113898 | 0 | 1.0 | 0.001 | |
bkrb1_human | 150 | 4.38x38 | TM4 | R => W | missense | 4.397e-05 | 5 | 113720 | 0 | 0.02 | 0.177 | |
bkrb1_human | 150 | 4.38x38 | TM4 | R => Q | missense | 0.000167 | 19 | 113752 | 0 | 0.12 | 0.22 | |
bkrb1_human | 151 | 4.39x39 | TM4 | R => W | missense | 6.154e-05 | 7 | 113744 | 0 | 0.04 | 0.333 | |
bkrb1_human | 151 | 4.39x39 | TM4 | R => P | missense | 8.779e-06 | 1 | 113902 | 0 | 0.15 | 0.349 | |
bkrb1_human | 151 | 4.39x39 | TM4 | R => Q | missense | 4.39e-05 | 5 | 113902 | 0 | 0.21 | 0.396 | |
bkrb1_human | 155 | 4.43x43 | TM4 | R => W | missense | 0.0001666 | 19 | 114018 | 0 | 0.0 | 0.899 | |
bkrb1_human | 155 | 4.43x43 | TM4 | R => Q | missense | 8.764e-06 | 1 | 114106 | 0 | 0.29 | 0.011 | |
bkrb1_human | 157 | 4.45x45 | TM4 | T => I | missense | 8.739e-06 | 1 | 114432 | 0 | 0.69 | 0.021 | |
bkrb1_human | 158 | 4.46x46 | TM4 | C => R | missense | 1.746e-05 | 2 | 114556 | 0 | 0.0 | 1.0 | |
bkrb1_human | 158 | 4.46x46 | TM4 | C => Y | missense | 8.729e-06 | 1 | 114564 | 0 | 0.0 | 1.0 | |
bkrb1_human | 165 | 4.53x53 | TM4 | G => R | missense | 8.64e-06 | 1 | 115742 | 0 | 0.0 | 0.998 | |
bkrb1_human | 176 | 4.64x65 | TM4 | R => Q | missense | 1.665e-05 | 2 | 120120 | 0 | 0.0 | 0.998 | LB (polar (charge-assisted hydrogen bond)) |
bkrb1_human | 176 | 4.64x65 | TM4 | R => L | missense | 8.325e-06 | 1 | 120120 | 0 | 0.0 | 0.999 | LB (polar (charge-assisted hydrogen bond)) |
bkrb1_human | 179 | ECL2 | Q => E | missense | 8.287e-06 | 1 | 120676 | 0 | 0.21 | 0.004 | ||
bkrb1_human | 181 | ECL2 | V => I | missense | 8.262e-06 | 1 | 121030 | 0 | 0.42 | 0.062 | ||
bkrb1_human | 181 | ECL2 | V => A | missense | 8.26e-06 | 1 | 121072 | 0 | 0.01 | 0.605 | ||
bkrb1_human | 188 | ECL2 | A => T | missense | 1.648e-05 | 2 | 121334 | 0 | 0.0 | 0.989 | ||
bkrb1_human | 188 | ECL2 | A => P | missense | 8.242e-06 | 1 | 121334 | 0 | 0.0 | 0.999 | ||
bkrb1_human | 189 | 45.50x50 | ECL2 | C => Y | missense | 8.241e-06 | 1 | 121350 | 0 | 0.0 | 0.997 | LB (polar (hydrogen bond with backbone), Van der Waals) |
bkrb1_human | 190 | 45.51x51 | ECL2 | I => F | missense | 8.24e-06 | 1 | 121356 | 0 | 0.11 | 0.702 | LB (hydrophobic, Van der Waals) |
bkrb1_human | 191 | 45.52x52 | ECL2 | L => V | missense | 0.002447 | 297 | 121370 | 0 | 0.0 | 1.0 | LB (polar (hydrogen bond with backbone), Van der Waals) |
bkrb1_human | 195 | 5.31x32 | TM5 | H => N | missense | 4.119e-05 | 5 | 121392 | 0 | 0.36 | 0.39 | |
bkrb1_human | 195 | 5.31x32 | TM5 | H => Y | missense | 8.238e-06 | 1 | 121392 | 0 | 0.09 | 0.828 | |
bkrb1_human | 195 | 5.31x32 | TM5 | H => R | missense | 0.0001565 | 19 | 121396 | 0 | 0.13 | 0.548 | |
bkrb1_human | 197 | 5.33x34 | TM5 | A => G | missense | 1.647e-05 | 2 | 121400 | 0 | 0.3 | 0.013 | |
bkrb1_human | 199 | 5.35x36 | TM5 | H => D | missense | 1.647e-05 | 2 | 121406 | 0 | 0.31 | 0.124 | |
bkrb1_human | 199 | 5.35x36 | TM5 | H => Y | missense | 8.237e-06 | 1 | 121406 | 0 | 0.19 | 0.028 | |
bkrb1_human | 214 | 5.50x50 | TM5 | P => L | missense | 2.471e-05 | 3 | 121406 | 0 | 0.0 | 0.976 | SodiumPocket MicroSwitch |
bkrb1_human | 216 | 5.52x52 | TM5 | A => T | missense | 0.0001071 | 13 | 121404 | 0 | 0.52 | 0.034 | |
bkrb1_human | 217 | 5.53x53 | TM5 | A => V | missense | 8.237e-06 | 1 | 121402 | 0 | 0.11 | 0.967 | |
bkrb1_human | 218 | 5.54x54 | TM5 | I => V | missense | 8.237e-06 | 1 | 121402 | 0 | 0.01 | 0.884 | |
bkrb1_human | 219 | 5.55x55 | TM5 | V => I | missense | 4.119e-05 | 5 | 121402 | 0 | 0.83 | 0.006 | |
bkrb1_human | 220 | 5.56x56 | TM5 | F => V | missense | 8.237e-06 | 1 | 121400 | 0 | 0.02 | 0.957 | |
bkrb1_human | 222 | 5.58x58 | TM5 | N => S | missense | 8.237e-06 | 1 | 121398 | 0 | 0.14 | 0.936 | SodiumPocket MicroSwitch |
bkrb1_human | 225 | 5.61x61 | TM5 | I => F | missense | 0.0008402 | 102 | 121394 | 2 | 0.0 | 0.933 | GP (contact) |
bkrb1_human | 228 | 5.64x64 | TM5 | S => F | missense | 8.239e-06 | 1 | 121372 | 0 | 0.0 | 0.95 | GP (contact) |
bkrb1_human | 230 | 5.66x66 | TM5 | R => Q | missense | 4.945e-05 | 6 | 121336 | 0 | 0.15 | 0.32 | GP (contact) |
bkrb1_human | 231 | 5.67x67 | TM5 | T => M | missense | 2.472e-05 | 3 | 121354 | 0 | 0.08 | 0.036 | GP (contact) |
bkrb1_human | 232 | 5.68x68 | TM5 | R => W | missense | 8.241e-05 | 10 | 121340 | 0 | 0.03 | 0.212 | GP (contact) |
bkrb1_human | 234 | 5.70x70 | TM5 | E => K | missense | 4.119e-05 | 5 | 121388 | 0 | 0.3 | 0.077 | |
bkrb1_human | 235 | 5.71x71 | TM5 | V => I | missense | 8.238e-06 | 1 | 121386 | 0 | 0.28 | 0.007 | GP (contact) |
bkrb1_human | 236 | 5.72x72 | TM5 | S => R | missense | 8.238e-06 | 1 | 121384 | 0 | 0.64 | 0.005 | GP (contact) |
bkrb1_human | 241 | ICL3 | G => R | missense | 0.006188 | 751 | 121368 | 11 | 0.1 | 0.944 | ||
bkrb1_human | 241 | ICL3 | G => R | missense | 8.239e-06 | 1 | 121368 | 0 | 0.1 | 0.944 | ||
bkrb1_human | 242 | ICL3 | G => S | missense | 1.648e-05 | 2 | 121382 | 0 | 0.26 | 0.608 | ||
bkrb1_human | 242 | ICL3 | G => V | missense | 8.238e-06 | 1 | 121382 | 0 | 0.19 | 0.119 | ||
bkrb1_human | 243 | ICL3 | R => C | missense | 0.0008403 | 102 | 121384 | 2 | 0.04 | 0.533 | ||
bkrb1_human | 243 | ICL3 | R => L | missense | 8.239e-06 | 1 | 121378 | 0 | 0.27 | 0.002 | ||
bkrb1_human | 243 | ICL3 | R => H | missense | 2.472e-05 | 3 | 121378 | 0 | 0.57 | 0.004 | ||
bkrb1_human | 249 | 6.34x34 | TM6 | T => R | missense | 4.119e-05 | 5 | 121386 | 0 | 0.0 | 0.979 | SodiumPocket MicroSwitch |
bkrb1_human | 250 | 6.35x35 | TM6 | A => V | missense | 0.0003378 | 41 | 121382 | 0 | 0.56 | 0.027 | |
bkrb1_human | 254 | 6.39x39 | TM6 | T => P | missense | 8.238e-06 | 1 | 121382 | 0 | 0.01 | 0.928 | |
bkrb1_human | 254 | 6.39x39 | TM6 | T => M | missense | 0.0001236 | 15 | 121374 | 0 | 0.13 | 0.493 | |
bkrb1_human | 256 | 6.41x41 | TM6 | V => M | missense | 5.767e-05 | 7 | 121386 | 0 | 0.0 | 1.0 | |
bkrb1_human | 262 | 6.47x47 | TM6 | C => F | missense | 5.767e-05 | 7 | 121390 | 0 | 0.0 | 1.0 | |
bkrb1_human | 263 | 6.48x48 | TM6 | W => R | missense | 4.943e-05 | 6 | 121392 | 0 | 0.02 | 1.0 | SodiumPocket MicroSwitch |
bkrb1_human | 267 | 6.52x52 | TM6 | H => Y | missense | 6.59e-05 | 8 | 121392 | 1 | 0.0 | 1.0 | |
bkrb1_human | 276 | 6.61x61 | TM6 | F => L | missense | 8.237e-06 | 1 | 121398 | 0 | 0.43 | 0.015 | LB (hydrophobic, Van der Waals) |
bkrb1_human | 278 | 6.63x63 | TM6 | V => M | missense | 8.237e-06 | 1 | 121404 | 0 | 0.24 | 0.22 | |
bkrb1_human | 280 | ECL3 | A => E | missense | 8.237e-06 | 1 | 121408 | 0 | 0.04 | 0.903 | ||
bkrb1_human | 282 | ECL3 | R => G | missense | 0.0005354 | 65 | 121408 | 0 | 0.35 | 0.019 | ||
bkrb1_human | 282 | ECL3 | R => Q | missense | 3.295e-05 | 4 | 121410 | 0 | 0.8 | 0.008 | ||
bkrb1_human | 282 | ECL3 | R => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.24 | 0.031 | ||
bkrb1_human | 290 | 7.31x30 | TM7 | I => T | missense | 4.118e-05 | 5 | 121410 | 0 | 0.67 | 0.007 | |
bkrb1_human | 291 | 7.32x31 | TM7 | D => N | missense | 2.471e-05 | 3 | 121410 | 0 | 0.39 | 0.9 | LB (polar (charge-assisted hydrogen bond)) |
bkrb1_human | 293 | 7.34x33 | TM7 | G => D | missense | 8.237e-06 | 1 | 121410 | 0 | 0.0 | 0.999 | |
bkrb1_human | 296 | 7.37x36 | TM7 | L => W | missense | 8.237e-06 | 1 | 121410 | 0 | 0.21 | 0.017 | |
bkrb1_human | 298 | 7.39x38 | TM7 | N => K | missense | 8.237e-06 | 1 | 121410 | 0 | 0.11 | 0.438 | LB (polar (hydrogen bond)) |
bkrb1_human | 303 | 7.44x43 | TM7 | T => A | missense | 1.647e-05 | 2 | 121410 | 0 | 0.38 | 0.01 | SodiumPocket MicroSwitch |
bkrb1_human | 310 | 7.51x51 | TM7 | V => L | missense | 0.0004449 | 54 | 121384 | 0 | 0.06 | 0.198 | |
bkrb1_human | 313 | 7.54x54 | TM7 | V => I | missense | 8.241e-06 | 1 | 121346 | 0 | 0.01 | 0.932 | |
bkrb1_human | 314 | 7.55x55 | TM7 | F => L | missense | 8.242e-06 | 1 | 121326 | 0 | 0.04 | 0.263 | GP (contact) |
bkrb1_human | 317 | 8.48x48 | H8 | R => W | missense | 0.0002391 | 29 | 121306 | 0 | nan | 0.487 | GP (contact) |
bkrb1_human | 317 | 8.48x48 | H8 | R => Q | missense | 0.006282 | 762 | 121300 | 22 | nan | 0.038 | GP (contact) |
bkrb1_human | 320 | 8.51x51 | H8 | R => M | missense | 8.245e-06 | 1 | 121288 | 0 | 0.0 | 0.959 | GP (contact) |
bkrb1_human | 321 | 8.52x52 | H8 | T => A | missense | 1.649e-05 | 2 | 121278 | 0 | nan | 0.045 | |
bkrb1_human | 322 | 8.53x53 | H8 | K => N | missense | 4.123e-05 | 5 | 121262 | 0 | 0.0 | 0.807 | |
bkrb1_human | 327 | 8.58x58 | H8 | Y => H | missense | 8.249e-06 | 1 | 121222 | 0 | 0.1 | 0.935 | |
bkrb1_human | 330 | C-term | C => Y | missense | 8.254e-06 | 1 | 121154 | 0 | 0.66 | 0.004 | ||
bkrb1_human | 336 | C-term | A => T | missense | 1.652e-05 | 2 | 121042 | 0 | 0.71 | 0.002 | ||
bkrb1_human | 337 | C-term | P => L | missense | 8.267e-06 | 1 | 120970 | 0 | 0.37 | 0.004 | ||
bkrb1_human | 338 | C-term | I => V | missense | 5.787e-05 | 7 | 120956 | 0 | 1.0 | 0.0 | ||
bkrb1_human | 348 | C-term | Q => P | missense | 8.37e-06 | 1 | 119472 | 0 | 0.09 | 0.003 | ||
bkrb1_human | 352 | C-term | R => W | missense | 0.0008288 | 98 | 118244 | 0 | nan | 0.482 | ||
bkrb1_human | 352 | C-term | R => Q | missense | 2.538e-05 | 3 | 118212 | 0 | nan | 0.003 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue